Regio‐ and Enantioselective Direct Oxyamination Reaction of Aldehydes Catalyzed by α,α‐Diphenylprolinol Trimethylsilyl Ether

Donors not required: External hydrogen-bond donors are not required for a highly regio- and enantioselective oxyamination reaction of aldehydes with nitrosobenzene (see scheme). The reaction proceeds in the presence of the structurally simple organocatalyst (−)-(S)-α,α-diphenylprolinol trimethylsilyl ether to afford the oxyaminated compounds in good yields.