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Rates of gluconeogenesis from lactate or pyruvate in hepatocytes from untrained rats were not increased by an acute (1 h) bout of exercise (running at 20 m/min). Hepatocytes from rats that had been exercise-trained for 1 month had lower rates of gluconeogenesis from lactate than cells from unexercised controls; the rates with pyruvate were identical. Hepatocytes from livers of trained animals immediately after 1 h of exercise synthesized glucose more rapidly and accumulated more citrulline than cells from resting rats.
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Bobyleva-Guarriero et al. (1986) studied this question.
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