Key result
Circulating miR-145 was a significant independent predictor of cardiac death or hospitalization for worsening heart failure after acute myocardial infarction (HR 7.174; 95% CI 4.208-12.229; p < 0.0001).
Why the study?
Does circulating miR-145 concentration predict cardiac death or hospitalization for worsening heart failure in patients with first STEMI after successful PCI?
Cohort (n=246)
Does circulating miR-145 concentration predict cardiac death or hospitalization for worsening heart failure in patients with first STEMI after successful PCI?
Hazard Ratio: 7.174 (95% CI 4.208–12.229)
p-value: p=< 0.0001
Circulating miR-145 measured on day 5 post-PCI is a strong independent predictor of cardiac death or heart failure hospitalization at one year in patients with first STEMI.
May refine post-STEMI risk stratification; hypothesis-generating and requires prospective validation before clinical adoption.
BACKGROUND: Recent reports have shown that miR-145 concentration correlates with infarct size. In this paper, we attempt to predict heart failure and cardiovascular death after acute myocardial infarction using circulating miR-145 concentration. METHODS: We assessed 246 patients with first ST-segment-elevation myocardial infarction who underwent successful percutaneous coronary intervention. We measured circulating miR-145, N-terminal fragment of the precursor B-type natriuretic peptide, myocardial-band creatine kinase, and cardiac troponin-I concentrations on day 5 after primary percutaneous coronary intervention and assessed their correlations with long-term clinical outcome. RESULTS: During the one-year follow-up period, 72 patients experienced primary composite cardiac events (cardiac death or hospitalization for worsening heart failure). Multivariable Cox proportional hazards analysis indicated that circulating miR-145 (hazard ratio 7.174, 95% confidence interval 4.208-12.229); p < 0.0001) was a significant independent predictor of cardiac events after adjustment for multiple confounders. CONCLUSION: Circulating miR-145 may be a novel biomarker for predicting long-term outcome after acute myocardial infarction.
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Dong et al. (2014) conducted a cohort in Acute myocardial infarction (n=246). Circulating miR-145 was evaluated on Primary composite cardiac events (cardiac death or hospitalization for worsening heart failure) (HR 7.174, 95% CI 4.208-12.229, p=< 0.0001). Circulating miR-145 was a significant independent predictor of cardiac death or hospitalization for worsening heart failure after acute myocardial infarction (HR 7.174; 95% CI 4.208-12.229; p < 0.0001).
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