chorea occurs when the function of the corpus striatum is disrupted, the specific abnormality in Sydenham's chorea is unknown. The response to valproic acid suggests that the defect affects the GABA neurotransmitter system. Possibly the difference in effectiveness of valproic acid between Sydenham's chorea and Huntington's chorea reflects the degree of severity of the pathologic process or, alternatively, indicates a difference in the pathogenesis of the two diseases.
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Taylor et al. (1981) studied this question.
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