Last week a committee of the U.S. Food and Drug Administration recommended that medicines containing acetaminophen, a commonly used painkiller sold under the brand name Tylenol and in many over-the-counter cold and flu remedies, carry stronger warnings about its dangerous side effects. Every year in the United States overdoses of the painkiller cause acute liver failure in as many as 800 people, one-third of whom die as a result. New results help explain just how acetaminophen harms the liver. They may also provide a target for treating liver failure due to overdoses of acetaminophen and perhaps of other drugs as well.
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Jean L. Marx (2002) studied this question.