Key result
A newly developed dextran sulfate cellulose bead LDL adsorbent successfully adsorbed atherogenic LDL cholesterol directly from whole blood while demonstrating excellent blood compatibility in vitro.
Why the study?
Does a newly developed dextran sulfate cellulose bead LDL adsorbent effectively and safely remove LDL cholesterol from whole blood in vitro?
Does a newly developed dextran sulfate cellulose bead LDL adsorbent effectively and safely remove LDL cholesterol from whole blood in vitro?
A newly developed dextran sulfate cellulose bead adsorbent effectively removes LDL cholesterol from whole blood with excellent blood compatibility in vitro, suggesting feasibility for LDL-hemoperfusion.
Does not support clinical use yet; leaves open feasibility of LDL-hemoperfusion pending in vivo validation.
We describe results from a feasibility study of a newly developed low-density lipoprotein (LDL) adsorbent designed for use in whole-blood infusion LDL-hemoperfusion. The adsorbent has almost the same chemical structure as the Liposorber adsorbent (dextran sulfate cellulose beads) but has a larger particle size. In whole-blood perfusion tests, the adsorbent adsorbed atherogenic LDL cholesterol directly from whole blood but left concentrations of high-density lipoprotein cholesterol largely unchanged. In whole-blood perfusion tests using fresh human donor blood or bovine blood anticoagulated with acid citrate dextrose solution or sodium citrate, the adsorbent showed minimal side effects in terms of blood cell activation, complement activation, and blood cell loss, suggesting that it has excellent blood compatibility. In addition, the adsorbent showed mechanical stability and absence of hemolysis. In conclusion, the new adsorbent showed the appropriate characteristics for an LDL adsorbent column for use in whole-blood infusion LDL-hemoperfusion.
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Kobayashi et al. (2002) studied this question. Newly developed low-density lipoprotein (LDL) adsorbent (dextran sulfate cellulose beads) was evaluated on Adsorption of atherogenic LDL cholesterol and blood compatibility. A newly developed dextran sulfate cellulose bead LDL adsorbent successfully adsorbed atherogenic LDL cholesterol directly from whole blood while demonstrating excellent blood compatibility in vitro.
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