Osteodystrophia Fibrosa Combined With Precocious Puberty and Exophthalmic Goiter

The bizarre syndrome characterized by severe, often asymmetric, disease of bones, melanotic pigmentation and precocious puberty in females has in recent years received considerable attention in the medical literature. A similar syndrome, but without precocious puberty, occurs, less frequently, in males. At present about 26 probable cases are reported, although a large number of less obvious cases undoubtedly exists. The literature on the subject has been reviewed by Albright and co-workers1and by McCune and Bruch.2Since the publication of these reviews several other cases have been reported, among them those of Mondor and co-workers,3Braid,4Robson and Todd,5Diez6and Sum (Footnotes continued on next page) merfeldt and Brown.7Unfortunately adequate postmortem material does not exist, although in the discussion by Musser and Barnwell of the paper of Albright's grouplbthere is a brief mention of an incomplete autopsy on a