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[structure] A [5 + 2] cycloaddition of the pyridinyl pi-complex (-)-1 (98% ee) to methyleneoxindole 2 afforded the spirooxindole complex (-)-3 in high enantiomeric purity. Complex (-)-3 was converted to pyrrolidine (-)-8 (97% ee), which is related to potent cytotoxic analogues of the spirotryprostatins alkaloids.
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Malinakova et al. (2000) studied this question.
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