Blood sera from patients suffering from castorbean-allergy will sensitize the skin of the Philippine crab-eating monkey, Macaca irus. The sensitized sites react to castorbean proteins, producing wheals and/or blanching characteristic of similar passive transfer tests (P.-K. tests) in nonallergic human volunteers. Skin reactions in the monkey are more easily interpreted when the colloidal dye Evans Blue is injected intravenously 5 or 10 minutes prior to challenge with the suspected allergenic material. The passive transfer of human serum antibodies into the skin of Macaca irus appears to be useful as a method which may be applied in lieu of the Prausnitz-Küstner test (on human volunteers) to avoid the grave risk of infection with serum hepatitis.
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Layton et al. (1961) studied this question.