Key result
7-DHC-derived oxysterols reduced cell viability in a dose- and time-dependent manner and triggered gene expression changes similar to those in Dhcr7-deficient Neuro2a cells.
Population
Neuro2a cells (control and Dhcr7-deficient)
Comparison
7-DHC-derived oxysterols vs Control (untreated) Neuro2a cells
Design
Preclinical
Authors
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May implicate 7-DHC oxysterols in SLOS pathogenesis; hypothesis-generating and requires in vivo validation before clinical consideration.
Accumulation of 7-DHC oxysterols may contribute to the pathophysiology of Smith-Lemli-Opitz syndrome by reducing cell viability and altering gene expression.
Korade et al. (2010) studied Smith-Lemli-Opitz syndrome. 7-dehydrocholesterol-derived oxysterols vs. control Neuro2a cells was evaluated on Cell viability and gene expression changes. 7-DHC-derived oxysterols reduced cell viability in a dose- and time-dependent manner and triggered gene expression changes similar to those in Dhcr7-deficient Neuro2a cells.
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