Plasma digoxin after parenteral administration Local reaction after intramuscular injection

Concentrations of digoxin in plasma after intravenous or intramuscular administration were measured in 8 sub;ects. Two hours after intramuscular in;ection concentrations were higher than after intravenous in;ection. A similar difference between the concentrations of digoxin in plasma was observed after intravenous and intramuscular administration to pigs. The shape of the curves was also similar to that of curves in man. Postmortem examination of the iniection sites in pigs revealed large necrotic areas after intramuscular in;ection of digoxin. The size of the necrotic area increased with the volume iniected. Necrotic areas were also demonstrated after intramuscular in;ection of the vehicle without digoxin, but they were smaller.