Key result
In patients with acute coronary syndrome, those with a left ventricular ejection fraction <50% had significantly higher relative expression levels of plasma hsa-miR-21-5p compared to those with an ejection fraction ≥50% (median 3.33 vs. 1.64; p=0.015).
Why the study?
Does reduced LVEF correlate with increased plasma hsa-miR-21-5p levels in patients with acute coronary syndrome?
Observational (n=26)
No
Does reduced LVEF correlate with increased plasma hsa-miR-21-5p levels in patients with acute coronary syndrome?
Elevated plasma levels of hsa-miR-21-5p are significantly associated with reduced left ventricular ejection fraction in patients presenting with acute coronary syndrome.
Myocardial ischemia that occurs during acute coronary syndrome (ACS) induces a cascade of pathophysiological processes which might lead to left ventricle dysfunction reflected by decreased left ventricular ejection fraction (LVEF) in echocardiographic examination. The enzymes regulating extracellular matrix (ECM) like matrix metalloproteinase 9 (MMP-9) also take part in this process. The MMP-9 activity is under control of a microRNA particle miR-21, which down-regulates its inhibitors. The study has shown, that in ACS population (n = 26) patients with LVEF < 50% presented increased miR-21 relative expression levels comparing to patients with LVEF ≥50% (3,33 vs 1,64; p = 0,015). Moreover, a significant negative correlation between LVEF and miR-21 in this group of patients has also been presented.
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Kowara et al. (2020) conducted an observational in Acute coronary syndrome (n=26). Reduced left ventricular ejection fraction (LVEF < 50%) vs. Preserved left ventricular ejection fraction (LVEF ≥ 50%) was evaluated on Relative expression level of plasma hsa-miR-21-5p (p=0.015). In patients with acute coronary syndrome, those with a left ventricular ejection fraction <50% had significantly higher relative expression levels of plasma hsa-miR-21-5p compared to those with an ejection fraction ≥50% (median 3.33 vs. 1.64; p=0.015).
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