Preclinical study demonstrates that steamed Codonopsis lanceolata attenuates alcohol-induced liver injury in mice, indicating therapeutic potential against ethanol-mediated oxidative stress.
Background and Objective: The roots of Codonopsis lanceolata have been used in traditional medicine for treatment of many diseases in China.Till now, there is no evidence on the liver protection effect of C. lanceolata on alcohol-induced liver injury.The purpose of this study was to investigate the hepatoprotective effect of steamed C. lanceolata (SCL) on ethanol induced liver injury in mice.Materials and Methods: Experimental mice were pretreated with different doses of SCL (100-400 mg kgG 1 ) for 2 weeks by gavage feeding.Biochemical markers and enzymatic antioxidants from serum, liver tissue were determined.Results: The results showed that the activities of ALT, AST and TG in serum, MDA level in liver tissue, decreased significantly (p<0.05) in the SCL-treated group compared with the alcohol group.On the contrary, the GSH level was increased markedly (p<0.05).Histopathological examination revealed that SCL (400 mg kgG 1 ) pre-treatment noticeably prevented alcohol-induced hepatocyte apoptosis and fatty degeneration.Moreover, LC-MS/MS analysis of SCL showed that it mainly contain Lobetyolin, Tangshenoside, Lancemasides F, Lancemasides B (Lancemasides E, Codonolaside), Lancemasides G, Lancemasides A (Codonoposide, Codonolaside) and Codonoposide.Conclusion: These results provide the evidence on possible application of SCL on acute alcohol-induced oxidative stress and liver damage in clinic.
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Xin et al. (2019) studied this question.
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