Key result
This review highlights the molecular mechanisms of hypertensive kidney disease and discusses the renoprotective role of the Hsp70 chaperone following AT1R blockade with losartan.
Why the study?
Hypertensive kidney disease pathophysiology increasingly implicates tubular injury, epithelial-mesenchymal transition, and fibrosis, prompting review of these molecular mechanisms and the role of Hsp70 after AT1R blockade.
Design
Review
Authors
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May inform mechanistic research on losartan in hypertensive nephropathy; leaves open clinical validation of Hsp70 as a target.
This review highlights the molecular mechanisms of hypertensive kidney disease, emphasizing the role of Hsp70 in angiotensin II-induced epithelial-mesenchymal transition and the renoprotective effects of AT1R blockade.
Costantino et al. (2021) conducted a review in Hypertensive nephropathy. Losartan was evaluated. This review highlights the molecular mechanisms of hypertensive kidney disease and discusses the renoprotective role of the Hsp70 chaperone following AT1R blockade with losartan.
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