Key result
A case series of 5 patients with confirmed COVID-19 identified major arterial thrombo-embolic manifestations in abdominal and lower-limb arteries, potentially causing rapid clinical worsening.
Why the study?
Increasing evidence suggested COVID-19 patients exhibit vascular complications due to a potential hypercoagulability status, prompting the reporting of thrombotic events in abdominal and lower-limb arteries.
Case Report (n=5)
No
Highlights a potential association between COVID-19 and major arterial thrombo-embolic complications.
Answers are grounded in this paper and cite their sources.
May warrant vigilance for arterial events in COVID-19; hypothesis-generating case series requiring prospective validation.
BACKGROUND: the outbreak of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in more than 150000 infected individuals and more than 20000 deaths in Italy. Viral acute pneumonitis is the major cause of morbidity and mortality, but there is increasing evidence that COVID-19 patients show a variable degree of vascular complications, due to a possible hypercoagulability status. OBJECTIVE: to report thrombotic events in abdominal and lower-limb arteries of COVID-19 patients (abdominal aorta, superior mesenteric artery, femoral arteries, cardiac, spleen and kidney). METHODS: we retrospectively reviewed our clinical records of patients with confirmed SARS-CoV-2 infection, admitted from March 1st to April 6th, 2020, to a tertiary care center in Brescia, Italy. We selected five patients with major arterial thrombo-embolic manifestations. RESULTS AND CONCLUSION: In our opinion, arterial thrombotic events may be more common in COVID-19 patients than in general population, possibly resulting in rapid worsening of patient conditions.
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Bonera et al. (2020) conducted a case report in COVID-19 (n=5). SARS-CoV-2 infection was evaluated on Major arterial thrombo-embolic manifestations. A case series of 5 patients with confirmed COVID-19 identified major arterial thrombo-embolic manifestations in abdominal and lower-limb arteries, potentially causing rapid clinical worsening.
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