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Optimization of a substituted 2-methylbenzofuran series led to the discovery of N , N -dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a glucokinase activator for treating Type 2 diabetes.
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Pfefferkorn et al. (2011) studied this question.
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