Towards a Personalized Cancer Gene Therapy: A Case of Clear Cell Renal Cell Carcinoma

An ideal cancer gene therapy would selectively destroy the cancer nodules with negligible effects on the surrounding not yet compromised tissue. This would be possible if the targeted genes are in command positions in the cancer but not in the normal cells. Logic dictates that, while being strongly protected by the homeostatic mechanisms, expression of a commander gene governs most major functional pathways by regulating the expression of numerous other genes. Owing to the cancer dependence on race, sex, age, genetic heritage, medical history, environmental and lifestyle associated risk factors each patient has most likely a distinct, dynamic and never repeatable set of commander genes. Here we introduce the