Why the study?
No vaccines or antiviral drugs are available for EV-D68, and a robust model to elucidate EV-D68 pathogenesis and evaluate treatment methods is lacking.
Population
7-day-old mice
Comparison
Intramuscular inoculation with a mouse-adapted EV-D68 strain
Design
Animal model study
Key result
Intramuscular inoculation of 7-day-old mice with a mouse-adapted EV-D68 strain caused progressive limb paralysis, high viral titers in skeletal muscle and spinal cord, and systemic inflammation.
Authors
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New EV-D68 paralysis model supports pathogenesis studies; leaves open therapeutic translation pending validation.
The development of a novel mouse model for EV-D68 infection provides a valuable tool for studying its neuropathological mechanisms and evaluating potential antiviral and vaccine therapies.
Duan et al. (2025) studied Enterovirus D68 infection. Intramuscular inoculation with mouse-adapted EV-D68 strain was evaluated on Progressive limb paralysis, viral load, and differentially expressed genes. Intramuscular inoculation of 7-day-old mice with a mouse-adapted EV-D68 strain caused progressive limb paralysis, high viral titers in skeletal muscle and spinal cord, and systemic inflammation.