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Ultrasensitive detection of nanoscale particles has applications in important fields ranging from environmental monitoring to analysis of viral structures. The authors show that the dissipative interaction in an optical microcavity of high quality factor allows the detection of single nanoparticles, even when the real part of an analyte's polarizability approaches zero. This innovative approach presents a significant step towards practical optical sensors for use in physics, analytical chemistry, environmental science, and molecular biology.
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