Key result
Sugammadex was a significant prognostic factor for first gas-passing time within 24 hours compared to neostigmine in patients undergoing robotic thyroidectomy (OR 4.60; 95% CI 1.47-14.36; p=0.005).
Why the study?
Postoperative bowel dysfunction poses difficulty during surgical recovery and reversal agents may affect bowel function, prompting comparison of sugammadex versus neostigmine/glycopyrrolate.
Does sugammadex improve postoperative bowel movement compared to a neostigmine/glycopyrrolate combination in patients undergoing robotic thyroidectomy?
Observational (n=122)
Does sugammadex improve postoperative bowel movement compared to a neostigmine/glycopyrrolate combination in patients undergoing robotic thyroidectomy?
Odds Ratio: 4.6 (95% CI 1.47–14.36)
p-value: p=0.005
Sugammadex use is associated with faster recovery of postoperative bowel motility compared to neostigmine in patients undergoing robotic thyroidectomy.
May support sugammadex for faster bowel recovery after robotic thyroidectomy; hypothesis-generating and requires RCT confirmation before practice change.
Postoperative bowel dysfunction poses difficulty to patients during their recovery from surgery, and reversal agents may affect bowel function. This study aimed to investigate and compare the effects of sugammadex and a neostigmine/glycopyrrolate combination on postoperative bowel movement in patients undergoing robotic thyroidectomy. The electronic medical records of 122 patients, who underwent robotic thyroidectomy between March 2018 and December 2020, were retrospectively reviewed. Demographic, clinical, and laboratory findings and the first gas-passing time after surgery were assessed. The number of patients with a first gas emission time over 24 h was significantly higher in the neostigmine group than in the sugammadex group (p = 0.008). Multivariate logistic regression analysis indicated that sugammadex was a prognostic factor for the first gas-passing time within 24 h (odds ratio = 4.60, 95% confidence interval 1.47–14.36, p = 0.005). Although postoperative bowel motility, based on the first gas emission time, was comparable, the number of patients with a first gas emission time within 24 h was significantly higher in the sugammadex group than in the neostigmine group. This shows that the use of sugammadex did not affect the delayed recovery of postoperative bowel motility after robotic thyroidectomy.
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Lee et al. (2022) conducted an observational in Patients undergoing robotic thyroidectomy (n=122). Sugammadex vs. Neostigmine/glycopyrrolate combination was evaluated on First gas-passing time within 24 h (OR 4.60, 95% CI 1.47-14.36, p=0.005). Sugammadex was a significant prognostic factor for first gas-passing time within 24 hours compared to neostigmine in patients undergoing robotic thyroidectomy (OR 4.60; 95% CI 1.47-14.36; p=0.005).
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