Oral Contraceptives-Thulin and Nermark JOU?4 LC performed in six of the cases with histological changes very similar to those seen in chlorpromazine-induced jaundice. The laboratory findings were a normal or only slightly raised alkaline phosphatase value and high transaminase levels. Certain features in the history were present in several cases: two had suffered from icterus and pruritus gravidarum, and this should be regarded as a contraindication to the use of contraceptive pills. The widespread use of oral contraceptives leads us to the supposition that this cause for jaundice is sometimes overlooked.
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Y. Shaker (1966) studied this question.