All articles of this category Treatment of indoles with a variety of electron deficient olefins under the influence of Yb(OTf) 3 ⋅3H 2 O leads to alkylation of the indoles at the 3-position in moderate to excellent yields. This mild coupling procedure may offer a convenient entry into the hapalindole class of marine alkaloids. conjugate addition - ytterbium triflate - indoles - hapalindole alkaloids
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Harrington et al. (2000) studied this question.