Reductive Amination of 2‐Amino‐2‐methyl‐1‐propanol and Ammonia to Produce 2‐Methyl‐1,2‐propanediamine over Raney Nickel Catalyst

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The selective synthesis of 2‐methyl‐1,2‐propyldiamine (MPDA) directly from 2‐amino‐2‐methyl‐1‐propanol (AMP) and ammonia via one‐pot reaction is reported for the first time. The effects of catalyst species and reaction variables on the synthetic performance of MPDA were systematically studied. In contrast to other catalysts, a high MPDA selectivity of 88.3% and AMP conversion of 45.6% were obtained over Raney Ni catalyst. The components of the final reaction mixtures were particularly dependent on the initial hydrogen pressure and stirring speed. Furthermore, a possible mechanism of the reaction was proposed on the basis of experimental results, which has great implications in the development of more efficient and higher selectivity catalysts.