April 1, 1995Infection and ImmunityOpen Access

Cytokine mRNA profiles in mononuclear cells in acute aseptic meningoencephalitis

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Population

Patients with acute aseptic meningoencephalitis (AM) and healthy controls

Design

Cross-sectional

Authors

VNV. NavikasLundbeck (Denmark)MHMats HaglundLandstinget i Kalmar län JLJoanne LinkKarolinska Institutet

Discussion

Member takes

Implication

Supports phase-specific immune monitoring in AM; hypothesis-generating for targeted therapies pending longitudinal validation.

Structured PICO

Population

Patients with acute aseptic meningoencephalitis (AM) and healthy controls

Comparator

Healthy controls and convalescent-phase patients

Outcome

Expression of mRNA encoding cytokines (IFN-gamma, IL-4, IL-6, IL-10, TGF-beta, TNF-alpha, lymphotoxin, perforin) in mononuclear cells from blood and cerebrospinal fluid (CSF)surrogate

Acute aseptic meningoencephalitis is characterized by distinct temporal cytokine mRNA profiles in blood and CSF mononuclear cells, reflecting an autonomous immune response in the CSF.

Cite This Study

Navikas et al. (1995) studied this question.

synapsesocial.com/papers/6a98574a883af1d6c8a6a276 https://doi.org/10.1128/iai.63.4.1581-1586.1995

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Cytokine mRNA profiles in mononuclear cells in acute aseptic meningoencephalitis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cytokine mRNA profiles in mononuclear cells in acute aseptic meningoencephalitis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider