Key result
Transcatheter edge-to-edge repair using the DragonFly™ system successfully reduced severe mitral regurgitation from grade 4+ to 1+ in a patient with papillary muscle rupture post-acute myocardial infarction.
Why the study?
Papillary muscle rupture is a serious complication of AMI causing severe mitral regurgitation and acute heart failure, and the feasibility and effectiveness of the DragonFly system in this setting needed exploration.
Case Report (n=1)
No
Transcatheter edge-to-edge repair (TEER) using the DragonFly system may be a feasible and effective treatment option for high-risk patients with acute severe mitral regurgitation caused by papillary muscle rupture post-AMI.
Case supports DragonFly feasibility in post-AMI papillary rupture; leaves open need for prospective trials before adoption.
BACKGROUND: Rupture of the papillary muscle is a serious complication of acute myocardial infarction (AMI), usually leading to mitral valve dysfunction and severe regurgitation, which in turn causes acute heart failure, posing a significant threat to the patient's life. CASE PRESENTATION: This case report aims to explore the feasibility and effectiveness of the DragonFly™ system in patients with papillary muscle rupture following AMI. We describe a 71-year-old male patient who was admitted due to chest tightness and chest pain, and upon examination, severe mitral regurgitation and papillary muscle rupture were found. Although the patient had missed the opportunity for emergency reperfusion, due to significant symptoms and heart failure, the cardiac team decided to perform a transcatheter edge-to-edge repair (TEER) of the mitral valve. During the procedure, guided by ultrasound and imaging, two valve clips were successfully implanted, significantly improving the mitral regurgitation. Postoperative assessment showed a reduction in regurgitation from 4 + to 1+, and the patient was discharged smoothly. CONCLUSIONS: Patients with AMI accompanied by papillary muscle rupture have poor condition. CLINICAL TRIAL NUMBER: Not applicable.
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Guo et al. (2025) conducted a case report in Papillary muscle rupture following acute myocardial infarction (n=1). Transcatheter edge-to-edge repair (TEER) using the DragonFly™ system was evaluated on Mitral regurgitation severity. Transcatheter edge-to-edge repair using the DragonFly™ system successfully reduced severe mitral regurgitation from grade 4+ to 1+ in a patient with papillary muscle rupture post-acute myocardial infarction.
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