An asymmetric one-pot hydrocyanation/Michael reaction of α-aryl diazoacetates with trimethylsilyl cyanide, tert-butanol, and N-phenylmaleimides has been realized. Using a chiral guanidinium salt/CuBr catalyst, a series of cyanide-containing pyrrolidine-2,5-diones could be obtained in good yields with excellent diastereo- and enantioselectivities.
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Ruan et al. (2020) studied this question.
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