Diblock Copolymer Formation via Self-Assembly of Cyclodextrin and Adamantyl End-Functionalized Polymers

Two water-soluble polymers poly(2-methyl-2-oxazoline) and poly( N -isopropylacrylamide) with complexing moieties (β-CD and adamantane, respectively) located at the chain ends were prepared via controlled techniques. To verify the interaction of the β-CD- and adamantane-type polymer end groups in aqueous solution, detailed complexation studies were carried out by 1 H NMR spectroscopy. It could be proved, that the polymers undergo self-assembly to form the corresponding supramolecular diblock structure. Furthermore, the double-hydrophilic block assembly was observed to be switchable to a hydrophilic−hydrophobic configuration by adjusting temperature leading to reversible aggregate formation.