Key result
Race-stratified polygenic risk score analyses may obscure healthcare disparities in Hispanic populations.
Why the study?
Current coronary artery disease polygenic risk scores may provide weaker predictions for populations with significant non-European ancestry, but this disparity may be masked when diverse Hispanic populations are aggregated into a single group.
Do polygenic risk scores for coronary artery disease provide different predictive power across Hispanic, non-Hispanic White, and non-Hispanic Black populations?
Cohort
Do polygenic risk scores for coronary artery disease provide different predictive power across Hispanic, non-Hispanic White, and non-Hispanic Black populations?
Answers are grounded in this paper and cite their sources.
Aggregating diverse Hispanic populations into a single group may mask disparities in the predictive power of polygenic risk scores for coronary artery disease.
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Clarke et al. (2022) conducted a cohort in Coronary artery disease. Polygenic risk scores (PRSs) for CAD vs. Different racial and ethnic groups was evaluated on Coronary artery disease (CAD), defined by ≥2 ICD diagnoses or CPT procedure codes for CAD in the electronic health record within a span of 12 months. Four validated coronary artery disease polygenic risk scores were evaluated across diverse racial and ethnic groups in the Million Veteran Program, though quantitative results are not available in the truncated abstract.
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