Naturally Acquired Rabies in White-Eared Opossum, Brazil

R abies is a viral zoonosis with high mortality rates caused by Lyssavirus rabies lineages (rabies virus, RABV) (1). Opossums of the genus Didelphis are marsupials widely distributed in the Americas, synanthropic in urban scenarios, and considered resistant to RABV (2). The main urban reservoirs of RABV in Brazil are nonhematophagous bats with distinct lineages and epidemiologic aspects (3). In 2021, passive surveillance programs detected an unusual case of rabies in a white-eared opossum (D. albiventris) by a RABV lineage of frugivorous bats of genus Artibeus spp. in Campinas, So Paulo state, Brazil, the 10th most urbanized city in the country (4). To elucidate the dynamics of this spillover, we describe the results of passive surveillance for rabies in bats and opossums in Campinas in 2021.