Key result
Coenzyme Q10 supplementation during a 12-week resistance training program provided no significant additional benefit on muscle strength, endurance, or quality of life compared to placebo in patients with post-polio syndrome.
Why the study?
Does coenzyme Q10 supplementation improve muscle strength, endurance, and quality of life in patients with post-polio syndrome undergoing resistance training?
RCT (n=14)
Double-blind
Parallel
No
Does coenzyme Q10 supplementation improve muscle strength, endurance, and quality of life in patients with post-polio syndrome undergoing resistance training?
Absolute Event Rate: 82% vs 83%
p-value: p=0.902
Coenzyme Q10 supplementation does not provide additional benefits to muscle function or quality of life in patients with post-polio syndrome undergoing resistance training.
CoQ10 adds no value to resistance training in post-polio syndrome; confirms lack of benefit and supports training alone.
OBJECTIVE: Coenzyme Q10 supplementation leads to increased muscle metabolism in patients with post-polio syndrome. The aim of this study was to investigate the effect of resistance training in combination with oral supplementation with coenzyme Q10 in patients with post-polio syndrome regarding muscle strength and endurance as well as functional capacity and health-related quality of life. DESIGN: Parallel randomized, controlled, double-blind pilot study. PATIENTS AND METHODS: A total of 14 patients (8 women and 6 men) with post-polio syndrome participated in a 12-week muscular resistance training, 3 days/week. The patients were randomized for oral supplementation with coenzyme Q10, 200 mg/day, or placebo. Measurements used were: sit-stand-sit test, timed up & go test, 6-minute walk test, muscle strength measurement by means of dynamic dynamometer and short-form (SF)-36 questionnaire. RESULTS: Muscle strength, muscle endurance and quality of life regarding mental health increased statistically significantly in all 14 patients. There was no significant difference between the coenzyme Q10 and placebo groups regarding muscle strength, muscle endurance and quality of life. CONCLUSION: There was no effect of coenzyme Q10 supplementation during resistance training on post-polio syndrome symptoms. Thus, supplementation with coenzyme Q10 has no beneficial effect on muscle function in patients with post-polio syndrome.
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Skough et al. (2008) conducted an RCT in Post-polio syndrome (n=14). Coenzyme Q10 vs. Placebo was evaluated on Muscle strength (Nm) after 12 weeks (p=0.902). Coenzyme Q10 supplementation during a 12-week resistance training program provided no significant additional benefit on muscle strength, endurance, or quality of life compared to placebo in patients with post-polio syndrome.
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