Top model: Heme–copper oxidase (HCO) contains a histidine–tyrosine cross-link in its heme a3/CuB oxygen reduction center. A functional model of HCO was obtained through the genetic incorporation of the unnatural amino acid imiTyr, which mimics the Tyr–His cross-link, and of the CuB site into myoglobin (see picture). Like HCO, this small soluble protein exhibits selective O2-reduction activity while generating little reactive oxygen species.
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Liu et al. (2012) studied this question.
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