The changes in seminal plasma LDH-X isoenzyme were investigated in 27 oligozoospermic patients treated with large doses of testosterone. The increase in this isoenzyme, proven to occur prior to the sperm count elevation, might possibly serve as a predictor enabling the choice of an optimal term for affecting conception. A high percentage of responders has been found in patients with severe oligozoospermia (less than 0.1 x 10(6) spermatozoa/ml), but with a high initial relative percentage of seminal plasma LDH-X. The determination of this parameter could be one of the criteria for the selection of patients who will probably respond to the therapy.
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Gavella et al. (1987) studied this question.
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