Depot iron is normally held in the body as a combination with ferritin, the iron-storage protein. A study of normal rats was undertaken concerning the deposition of iron in ferritin after the animals were given a large intraperitoneal dose of iron. A peculiarity of behavior of ferritin in the small intestine after such injection led to the observation that the intestine is able to incorporate ferritin iron through its serosal surface.
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Thirayothin et al. (1962) studied this question.