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The synthesis of cis-2-ethyl-8-formyl-3,4,7,8-dihydro-2H-oxocin-3-one and its derivatives, key intermediates for synthesis of laurencin, from methyl 2-ethyl-2,5-dihydro-2-furoates is described. The structure and configuration of these compounds and the synthetic intermediates are defined clearly on the basis of the chemical and spectral evidence.
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Masamune et al. (1979) studied this question.
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