Inter- and Intraindividual Variation of Gene Expression in Human Skin Following Grape Consumption and/or Exposure to Ultraviolet Irradiation

This is the authors' abstract. We don't add key points for this paper.

Based on promising preclinical results, translational work has shown that grape consumption could increase the resilience of skin to UV irradiation in a subset of human subjects. With four human subjects who did not appear resilient to UV-exposure following grape consumption, we currently demonstrate grape consumption: (1) diminished UV-induced malondialdehyde generation, (2) modulated the plasma lipidome, and (3) induced expression of a suite of genes in skin capable of safeguarding against environmental factors like UV radiation, chemicals, and pathogens, e.g., keratinization and cornification. This is the first report demonstrating gene modulation resulting from grape consumption in a human somatic tissue other than peripheral blood monocytes. Expression patterns show remarkable inter- and intraindividual differences but were omnipresent and interpretable by applying bioanalytics. Consistently, our overall supposition is that grape phytochemicals interact with the microbiome, followed by transmission through the gut–organ axes, resulting in modulation of gene expression and subsequent downstream responses.