In vitro study reveals potent antibacterial activity of a novel dibenzofuran phloroglucinol against pathogenic bacteria, indicating its potential for developing new antimicrobial agents.
Our continuation on the bio-assay guided isolation from Myrtus communis Linn. led to the discovery of a new dibezofuran type phloroglucinol 1,1'-(1,3,7,9-tetrahydroxydibenzo[b,d]furan-2,8-diyl)bis(ethan-1-one) 1. The structure was established through detailed spectroscopic studies including one and two dimensional NMR spectroscopy and electrospray ionization high resolution mass spectrometer (ESI-HRMS). The crude acetone extract from M. communis (AMA), dichloromethane fraction (DCM), and the isolated pure compound 1 were tested against pathogenic bacteria. Compound 1 displayed higher antibacterial activity against the Gram-positive and Gram-negative Staphlocococus aureus and Escherichia coli respectively as compared to the crude extract and fractions.
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Khan et al. (2019) studied this question.
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