Key result
The minor allele of rs2075650 and the major allele of rs646776 were significantly associated with increased risk of severe carotid artery disease, independent of their effects on HDL and LDL levels.
Why the study?
Do recently identified dyslipidemia risk alleles increase the risk of severe carotid artery disease?
Case-Control (n=915)
Yes
Do recently identified dyslipidemia risk alleles increase the risk of severe carotid artery disease?
Effect estimate: beta 0.56
p-value: p=0.00091
Genetic variations at the 1p13.3 and 19q13.2 loci contribute to the risk of severe carotid artery disease, likely by increasing LDL particle number and promoting smaller, denser LDL particles, respectively.
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These alleles may refine carotid risk prediction beyond lipids; hypothesis-generating and requires prospective validation before clinical use.
Ronald et al. (2009) conducted a case-control in Carotid artery disease (CAAD) (n=915). Dyslipidemia-associated SNPs (rs646776 and rs2075650) vs. Reference alleles was evaluated on Severe carotid artery disease (CAAD) stenosis status (≥80% vs ≤15%) (beta 0.56, p=0.00091). The minor allele of rs2075650 and the major allele of rs646776 were significantly associated with increased risk of severe carotid artery disease, independent of their effects on HDL and LDL levels.
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