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Two new polypyridyl complexes [Ru(ttp)(L1)Cl]PF6(1) and [Ru(ttp)(L2)Cl]PF6(2) with noninnocent o-benzoquinonediimine (L1; bqdi) and 4,5-dimethyle-o-benzoquinonediimine (L2; 4,5-di-Mebqdi) ligands were synthesized and characterized (ttp = -p-toloyle-2,: ,-terpyridine). Cyclic voltammetry studies suggest that noninnocent ligands are coordinated in their benzoquinonediimine form. Preliminary ruthenium complexes-induced DNA dysfunction was studied onE. coliGM109 DNA by means of melting temperature analysis (Tm). Our results suggest that complex (2) inhibited DNA function more strongly compared to (1). Antibacterial activities of the complexes againstE. colibacteria were studied, and Minimum inhibitory concentration (MIC) values were evaluated. Both complexes showed great antibacterial activities.
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Taheri et al. (2013) studied this question.
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