Why the study?
Despite the high prevalence of iron deficiency in patients with HFrEF, its impact on clinical outcomes, mortality, and physiological parameters remains under ongoing investigation.
Does iron deficiency increase mortality and worsen clinical symptoms in patients with HFrEF?
Population
371 patients with HFrEF at King Edward Memorial Hospital, India
Comparison
Iron-deficient vs iron-replete patients
Design
Prospective cohort study
Key result
Iron deficiency in patients with heart failure with reduced ejection fraction was associated with a 1.9-fold increased risk of mortality compared to iron-replete patients (RR 1.9).
Authors
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Associated with higher HFrEF mortality; hypothesis-generating for iron repletion trials.
Cohort (n=371)
No
Does iron deficiency increase mortality and worsen clinical symptoms in patients with HFrEF?
Relative Risk: 1.9 (95% CI 0.9884–3.757)
Absolute Event Rate: 12.42% vs 6.45%
p-value: p=0.0541
Iron deficiency is present in 50% of HFrEF patients and is associated with a nearly twofold increased risk of mortality and worse clinical symptoms.
Sarate et al. (2024) conducted a cohort in Heart failure with reduced ejection fraction (HFrEF) (n=371). Iron deficiency vs. No iron deficiency (iron replete) was evaluated on Mortality (RR 1.9, 95% CI 0.9884-3.7570, p=0.0541). Iron deficiency in patients with heart failure with reduced ejection fraction was associated with a 1.9-fold increased risk of mortality compared to iron-replete patients (RR 1.9).