Accelerated crystal growth of sulphathiazole by temperature cycling

A novel method is suggested for accelerating the physical changes in suspensions. The suspension is stirred in a jacketed vessel and is alternately heated and cooled. Results indicate a rectilinear relationship between the median particle size of sulphathiazole in suspension and the number of temperature cycles. Crystal growth is measured by the Coulter counter and growth rates are compared arithmetically to indicate which additives (surface-active agents) may be used to inhibit crystal growth.