A Pharmacological Approach to the Nature of the Autoregulation of the Renal Blood Flow

The dog's kidney perfused with its own blood showed a good performance. of the autoregulation of the blood flow.2. The autoregulation of the renal blood flow was liable to diminish and disappear spontaneously.3. The autoregulation was abolished with the infusion of papaverine, theophylline, acetylcholine or norepinephrine.4. Dipyridamol, infused into the renal artery, restored the autoregulation of the renal blood flow from the deprived state of the spontaneous failure, but not from that induced by drugs. Its significance was discussed in relation to, the adenine nucleotide metabolism of the renal blood vessels.This work was supported by grants of Pharmacological Research Foundation, inc. and Ministry of Education (No.91043). The authors express thanks to Mrs. K. YOSHIO for typewriting this manuscript.