Key result
High blood pressure in conscious rats was associated with a steeper scaling slope of heartbeat intervals, a dynamic successfully modeled using a modified Chua circuit.
Sensitivity of blood pressure to sympathetic control likely determines the scaling slopes of heartbeat intervals, which can be effectively modeled using a modified Chua circuit.
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Does not warrant changes in hypertension care; leaves open whether Chua circuit models advance sympathetic-heart rate research.
The low-frequency portion of the power spectrum of human heartbeat intervals exhibits a 1/f-like scaling behavior. Despite its clinical significance, the mechanism remains unknown. By recording heartbeat intervals, renal sympathetic nerve activity (SNA), and blood pressure (BP) in conscious rats with normal or high BP, we reported that the scaling slope of heartbeat intervals is steeper in the rats with high BP, and that SNA leads to heartbeat interval and BP changes, and also the dynamics of these three variables, heartbeat intervals, BP, and SNA, results from a low-dimensional chaos. This hemodynamics is modeled excellently by modification of a known chaotic electrical circuit, Chua circuit. Increasing the resistive element between SNA and BP in the circuit increases the scaling slope and abolishes the low-dimensional chaos. Therefore, sensitivity of BP to sympathetic control is likely to determine the scaling slopes of heartbeat intervals in health and disease.
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Osaka et al. (2004) studied Normal or high blood pressure. High blood pressure vs. Normal blood pressure was evaluated on Scaling slope of heartbeat intervals and low-dimensional chaos. High blood pressure in conscious rats was associated with a steeper scaling slope of heartbeat intervals, a dynamic successfully modeled using a modified Chua circuit.
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