Abstract magnified image We herein report conventional and microwave‐assisted methods for the synthesis of a series of compounds containing some bivalent ion chelating requirements useful to exert potential HIV‐1 integrase (IN) enzyme inhibition activity. The biological screening highlighted that only derivative 5 proved to be a strand‐transfer step inhibitor of the virus integration process at micromolar concentration. J. Heterocyclic Chem., (2009).
No takes yet. Share an insight, caveat, or question.
Ferro et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: