Psoriatic hyperproliferative epidermis is characterized by a decreased β2‐adrenergic adenylate cyclase response as well us by altered differentiation markers that include decreased loricrin and increased involucrin, Using a quantitative reverse transcription‐polymerase chain reaction, we analysed the expression of β2‐adrenergic receptor‐mRNA. loricrin‐mRNA, and involucrin‐mRNA in the epidermis of five patients with psoriasis vulgaris. The mRNAs of the β2‐adrenergic receptor and loricrin in the involved epidermis were significantly decreased, by 0.35‐fold (P < 0.01) and 0.55‐fold (P < 0.05) respectively, compared with uninvolved epidermis. In contrast, the involucrin mRNA expression of the involved epidermis was significantly increased, by 3.77‐fold (P < 0.01). No significant difference in β‐actin mRNA transcripts was detected between the involved and the uninvolved epidermis. These results indicate that the altered expression of the β2‐adrenergic receptor, loricrin. and involucrin. in the psoriatic involved epidermis, is associated with different amounts of each mRNA transcripts.
No takes yet. Share an insight, caveat, or question.
Takahashi et al. (1996) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: