Key result
The Micra Transcatheter Pacing System demonstrated a significantly lower mean pacing threshold at 12 weeks compared to a traditional single-lead pacemaker (0.94 V vs 1.85 V; P<0.0001) in pigs.
Why the study?
Does the Micra Transcatheter Pacing System maintain electrical performance and safety compared to a traditional leaded pacemaker in Yucatan mini pigs?
Population
20 Yucatan mini pigs
Comparison
Micra Transcatheter Pacing System implanted in… vs Medtronic single-lead pacemaker implanted in the…
Design
Preclinical
Follow-up
12 weeks
Authors
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Merits human trials of leadless systems; leaves open translation to clinical outcomes and safety.
Does the Micra Transcatheter Pacing System maintain electrical performance and safety compared to a traditional leaded pacemaker in Yucatan mini pigs?
Absolute Event Rate: 0.94% vs 1.85%
p-value: p=< 0.0001
The miniaturized Micra transcatheter pacemaker demonstrated superior pacing thresholds and a similar safety profile compared to a traditional leaded pacemaker in a porcine model over 12 weeks.
Bonner et al. (2015) studied this question. Micra Transcatheter Pacing System (TPS) vs. Medtronic single-lead pacemaker (SLP) was evaluated on Mean pacing threshold at 12 weeks (p=< 0.0001). The Micra Transcatheter Pacing System demonstrated a significantly lower mean pacing threshold at 12 weeks compared to a traditional single-lead pacemaker (0.94 V vs 1.85 V; P<0.0001) in pigs.
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