Efficient Synthesis of 2‐Substituted Indoles Based on Palladium(II) Acetate/Tri‐tert‐butylphosphine‐Catalyzed Alkynylation/Amination of 1,2‐Dihalobenzenes

A simple, efficient palladium(II) acetate/tri‐tert‐butylphosphine‐catalyzed indole synthesis from o‐alkynylhalobenzenes, readily available from 1,2‐dihalobenzenes, has been achieved in good to excellent yields. A one‐pot, Pd(OAc)2/t‐Bu3P‐catalyzed sequential reaction from 1‐chloro‐2‐iodobenzene, phenylacetylene and amines has also been achieved in good yields.