Molecular Understanding of Osteoclast Differentiation and Physiology

s function [1,2]. Osteoblasts, which build bone, are derived from a mesenchymal progenitor cell that can also differentiate into marrow stromal cells and adipocytes [3]. Osteoclasts, originating from hemopoietic progenitors of the monocyte/macrophage lineage, immigrate into bone via the blood stream and resorb mineralized tissues [1,2,4]. Bone through this continuous dynamic remodeling provides structural integrity, skel-etal strength, and a reservoir for hematopoiesis. Elevated osteoclast numbers and activity cause osteoporosis, Paget