Key result
Each quartile increase in the glycemia risk index was associated with a 1.30-fold higher prevalence of increased arterial stiffness in adults with type 2 diabetes (OR 1.30; 95% CI 1.01-1.68).
Why the study?
The study was conducted to investigate the association between the glycemia risk index, a novel continuous glucose monitoring composite metric, and arterial stiffness in patients with type 2 diabetes.
Is a higher glycemia risk index associated with increased arterial stiffness in adults with type 2 diabetes?
Cross-Sectional (n=342)
Yes
Is a higher glycemia risk index associated with increased arterial stiffness in adults with type 2 diabetes?
Odds Ratio: 1.3 (95% CI 1.01–1.68)
p-value: p=< 0.05
Higher glycemia risk index derived from continuous glucose monitoring is independently associated with increased arterial stiffness in patients with type 2 diabetes.
AIM: This study aims to investigate the association of glycemia risk index (GRI), a novel composite metric derived from continuous glucose monitoring (CGM), with arterial stiffness in patients with type 2 diabetes. MATERIALS AND METHODS: A total of 342 adults with type 2 diabetes were enrolled between April and June 2023 from 11 communities in Shanghai, China. Medical examinations, including measurements of anthropometric parameters, blood pressure, and venous blood samples were conducted. Brachial-ankle pulse wave velocity (baPWV) was examined to evaluate arterial stiffness. All the participants underwent a 14 day CGM recording and GRI was calculated from the CGM data. RESULTS: The mean age was 70.3 ± 6.8 years, and 162 (47.4%) were male. Participants with a higher baPWV had significantly higher levels of GRI and hyperglycemia component (both P for trend < 0.05). Linear regression revealed the significant positive linear associations of the GRI with baPWV in unadjusted or adjusted models (All P < 0.05). In the multivariable logistic analysis, each increase in the GRI quartile was associated with a 1.30-fold (95% CI 1.01-1.68, P for trend < 0.05) higher prevalence of increased arterial stiffness after adjustment for age, sex, BMI, diabetes duration, current smoking status, blood pressure, and lipid profile. Subgroup analyses showed that the association between the GRI quartiles and increased arterial stiffness was stronger among participants with a diabetes duration ≥15 years (P for interaction = 0.014). CONCLUSION: Glycemia risk index assessed by continuous glucose monitoring is associated with increased arterial stiffness in type 2 diabetes.
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Cai et al. (2024) conducted a cross-sectional in type 2 diabetes (n=342). Glycemia risk index (GRI) vs. Lower GRI quartiles was evaluated on increased arterial stiffness (evaluated by brachial-ankle pulse wave velocity) (OR 1.30, 95% CI 1.01-1.68, p=< 0.05). Each quartile increase in the glycemia risk index was associated with a 1.30-fold higher prevalence of increased arterial stiffness in adults with type 2 diabetes (OR 1.30; 95% CI 1.01-1.68).
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