Key result
Bone marrow AT2 receptor deficiency significantly increased atherosclerotic lesion area by 51% in apoE-deficient mice compared to wild-type bone marrow (P<0.05).
Population
Bone marrow chimera apoE-deficient (apoE(-/-)) mice
Comparison
Bone marrow repopulation with AT2-deficient… vs Bone marrow repopulation with wild-type (Agtr2)…
Design
Preclinical
Follow-up
2 months
Authors
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Suggests bone marrow AT2 receptors protect against atherosclerosis; hypothesis-generating in mice, leaves open human translation.
Effect estimate: 51% increase
p-value: p=< 0.05
Bone marrow AT2 receptor deficiency aggravates atherosclerosis development in apoE-deficient mice, likely by impairing macrophage LXRβ-mediated anti-atherogenic actions.
Kato et al. (2014) studied Atherosclerosis. Bone marrow AT2 receptor deficiency (Agtr2-/-) vs. Wild-type bone marrow cells (Agtr2+/+) was evaluated on Atherosclerotic lesion area (51% increase, p=< 0.05). Bone marrow AT2 receptor deficiency significantly increased atherosclerotic lesion area by 51% in apoE-deficient mice compared to wild-type bone marrow (P<0.05).
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