In this communication we report the synthesis and characterization of a defined-sequence, alternating purine-pyrimidine polymer with a 10-base pair repeating unit: poly[d(CGCGCGTGCA)]. It is seen that the polymer can undergo a right-left-hand helical transition, but the conformational transition requires much higher salt concentration than with poly[d(G-C)]. The results are interpreted in terms of interaction of the polymer with solvent molecules.
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Schorschinsky et al. (1986) studied this question.
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